The Black Volta River Basin plays a key role in supporting the life in and around it. To support sustainable planning and management of the basin, the study assessed the impacts of climate change on the streamflow and sediment yield in the basin. The sensitivity of the flow to changes in land-use/- cover (LULC) was also investigated. A multi-model ensemble approach was used, with outputs from three RCM/GCM pairs used to drive the Soil and Water Assessment Tool model. Results of the study showed that changes in climate would result in an increase in flow and sediment loads in the basin until the end of the 21st century. The LULC change sensitivity analysis, on the other hand, showed statistically insignificant changes.