This study aimed to assess the effects Climate and Land Use/Land Cover Change on groundwater resources in Koda catchment (Mali). Investigations and Analyses carried out in this study include (a) the determination of the dynamics of LULC change trough Envi software and its effects on groundwater and (b) the use of GCM/RCM pairs to drive Gardenia model under RCP 4.5 and RCP 8.5 scenarii. Visual Modflow was used to simulate groundwater flow in Koda. The results show a decline of 8.4 % in groundwater recharge associated to LULC change in the study area. The groundwater level and recharge are decreasing over time from 1987-2050. The severe projected drought events occur from 2029 to 2039.